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Piccirilli, Joseph A.

One or more keywords matched the following items that are connected to Piccirilli, Joseph A.

Item Type	Name
Concept	Nucleic Acid Conformation
Academic Article	RNA catalysis by a group I ribozyme. Developing a model for transition state stabilization.
Academic Article	Synthesis of 3'-thioribonucleosides and their incorporation into oligoribonucleotides via phosphoramidite chemistry.
Academic Article	Aminoacyl esterase activity of the Tetrahymena ribozyme.
Academic Article	Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome.
Academic Article	Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage.
Academic Article	Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns.
Academic Article	Investigation of the proposed interdomain ribose zipper in hairpin ribozyme cleavage using 2'-modified nucleosides.
Academic Article	Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet.
Academic Article	A packing-density metric for exploring the interior of folded RNA molecules.
Academic Article	An atomic mutation cycle for exploring RNA's 2'-hydroxyl group.
Academic Article	General acid catalysis by the hepatitis delta virus ribozyme.
Academic Article	2'-mercaptonucleotide interference reveals regions of close packing within folded RNA molecules.
Academic Article	Synthetic antibodies for specific recognition and crystallization of structured RNA.
Academic Article	Efficient synthesis of [2'-18O]uridine and its incorporation into oligonucleotides: a new tool for mechanistic study of nucleotidyl transfer reactions by isotope effect analysis.
Academic Article	Structure and function converge to identify a hydrogen bond in a group I ribozyme active site.
Academic Article	Crystal structure of the catalytic core of an RNA-polymerase ribozyme.
Academic Article	Nucleotide analogues to investigate RNA structure and function.
Academic Article	The electrostatic character of the ribosomal surface enables extraordinarily rapid target location by ribotoxins.
Academic Article	Nucleobase-mediated general acid-base catalysis in the Varkud satellite ribozyme.
Academic Article	The mechanism of RNA strand scission: an experimental measure of the Brønsted coefficient, beta nuc.
Academic Article	Linkage between substrate recognition and catalysis during cleavage of sarcin/ricin loop RNA by restrictocin.
Academic Article	Biochemistry. Toward understanding self-splicing.
Academic Article	The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues.
Academic Article	Metal-ion rescue revisited: biochemical detection of site-bound metal ions important for RNA folding.
Academic Article	2'-Fluoro substituents can mimic native 2'-hydroxyls within structured RNA.
Academic Article	Recognition of guanosine by dissimilar tRNA methyltransferases.
Academic Article	Crystal structure of an RNA polymerase ribozyme in complex with an antibody fragment.
Academic Article	Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis.
Academic Article	Structural inference of native and partially folded RNA by high-throughput contact mapping.
Academic Article	Electrostatic interactions guide the active site face of a structure-specific ribonuclease to its RNA substrate.
Academic Article	A rearrangement of the guanosine-binding site establishes an extended network of functional interactions in the Tetrahymena group I ribozyme active site.
Academic Article	A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination.
Academic Article	Synthesis, properties, and applications of oligonucleotides containing an RNA dinucleotide phosphorothiolate linkage.
Academic Article	A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore.
Academic Article	Experimental and computational analysis of the transition state for ribonuclease A-catalyzed RNA 2'-O-transphosphorylation.
Academic Article	Synthesis and incorporation of the phosphoramidite derivative of 2'-O-photocaged 3'-s-thioguanosine into oligoribonucleotides: substrate for probing the mechanism of RNA catalysis.
Academic Article	Evidence for a group II intron-like catalytic triplex in the spliceosome.
Academic Article	Determination of hepatitis delta virus ribozyme N(-1) nucleobase and functional group specificity using internal competition kinetics.
Academic Article	Transition State Features in the Hepatitis Delta Virus Ribozyme Reaction Revealed by Atomic Perturbations.
Academic Article	A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair.
Academic Article	Integration of kinetic isotope effect analyses to elucidate ribonuclease mechanism.
Academic Article	Effect of Zn2+ binding and enzyme active site on the transition state for RNA 2'-O-transphosphorylation interpreted through kinetic isotope effects.
Academic Article	Crystal structure of the Varkud satellite ribozyme.
Academic Article	An active site rearrangement within the Tetrahymena group I ribozyme releases nonproductive interactions and allows formation of catalytic interactions.
Academic Article	Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
Academic Article	Laboratory evolution of artificially expanded DNA gives redesignable aptamers that target the toxic form of anthrax protective antigen.
Academic Article	RNA-Puzzles Round III: 3D RNA structure prediction of five riboswitches and one ribozyme.
Academic Article	Synthesizing topological structures containing RNA.
Academic Article	Evidence That Nucleophile Deprotonation Exceeds Bond Formation in the HDV Ribozyme Transition State.
Academic Article	Hachimoji DNA and RNA: A genetic system with eight building blocks.
Academic Article	Comparison of the Structures and Mechanisms of the Pistol and Hammerhead Ribozymes.
Academic Article	A conserved RNA structural motif for organizing topology within picornaviral internal ribosome entry sites.
Academic Article	Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation.
Academic Article	Branched kissing loops for the construction of diverse RNA homooligomeric nanostructures.
Academic Article	The hammerhead self-cleaving motif as a precursor to complex endonucleolytic ribozymes.
Academic Article	The SARS-CoV-2 Programmed -1 Ribosomal Frameshifting Element Crystal Structure Solved to 2.09 Å Using Chaperone-Assisted RNA Crystallography.
Academic Article	Structural basis for substrate binding and catalysis by a self-alkylating ribozyme.
Academic Article	Structural Basis for Fluorescence Activation by Pepper RNA.
Academic Article	Dissociative Transition State in Hepatitis Delta Virus Ribozyme Catalysis.
Academic Article	Rapid Kinetics of Pistol Ribozyme: Insights into Limits to RNA Catalysis.

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Nucleic Acid Conformation